Glomerular Filtration Rate in Kidney Disease


The new classification of kidney disease is based on GFR, a measure that is accepted as the best overall measure of kidney function. Stages 2 and 3 carry the caveat that elderly people may have reduced GFRs that are age related and not related to chronic kidney disease. GFRs are calculated based on a creatinine level measured in a spot urine specimen that takes into account factors such as patient's age, gender, race, and body size.

CHRONIC KIDNEY DISEASE STAGES

 STAGE

GFR Status

 GFR
(mL/min per 1.73 m2)

 1
 Kidney disease with normal GFR

 > 90

 2
 Mildly impaired GFR

60 - 89

 3
 Moderately impaired GFR

 30 - 59

 4
 Severely impaired GFR

 15 - 29

 5
 Kidney failure

 < 15

PROTEINURIA
  MEN WOMEN
Normal <17 mg/dL <25 mg/dL
Microalbuminuria 17-255 mg/dL 25-355 mg/dL
Proteinuria >255 mg/dL >355 mg/dL

About 10 million Americans have stage 1 kidney disease, nearly 22 million have stage 2 disease, nearly 6 million have stage 3, 360,000 have stage 4, and 300,000 have stage 5.


Source
Internal Medicine News. July 15, 2001 (Andrew Levy, MD, Chief of Nephrology, Tufts-New England Medical Center)

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